The most effective treatment is treatment with botox. Only localized hyperhidrosis can be treated with Botox, as only the areas that are injected will feel the effect. Generalized sweating is rather treated with tablets to inhibit the sweating.
Botox is a muscle relaxant that blocks the nerve impulses from the sweat glands, so you produce less sweat. This is done by injecting Botox deep into the skin where the most active sweat glands have been located. The effect will not spread to other places in the body where Botox has been injected.
The effect itself lasts for 4-6 months, so it is not a permanent solution. It may still be a better alternative than using daily medication and creams to keep the sweating problem at bay. If you repeat the treatment over time, the sweat glands will also become less active, and the effect will last all the longer.
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